Aims: The lack of disease-modifying treatments for osteoarthritis OA is linked to a shortage of suitable biomarkers. This study combines multi-molecule synovial fluid analysis with machine learning to produce an accurate diagnostic biomarker model for end-stage knee OA esOA. Methods: Synovial fluid SF from patients with esOA, non-OA knee injury, and inflammatory knee arthritis were analyzed for 35 potential markers using immunoassays. Partial least square discriminant analysis PLS-DA was used to derive a biomarker model for cohort classification.
Pulse-Dose Radiofrequency for Knee Osteoartrithis | SpringerLink
Knee osteoarthritis OA is a leading cause of disability in the elderly. The purpose of this study was to investigate the effectiveness of pulse-dose radiofrequency PDRF in patients with chronic pain refractory to conservative therapies. Mean VAS scores before the procedures was 6. No patients developed complications. This study successfully investigated the effectiveness of PDRF in patients with chronic pain unresponsive to conservative therapies. PDRF seems to be an effective and reliable technique for palliative management of chronic pain in patients with knee OA. This is a preview of subscription content, access via your institution.